Reduced Immune Activation During Tenofovir–Emtricitabine Therapy in HIV-Negative Individuals
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چکیده
منابع مشابه
Reduction of immune activation with chloroquine therapy during chronic HIV infection.
Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR(+) CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, wa...
متن کاملIdentification of Immune Activation Profiles That May Predict Morbidity During Antiretroviral Therapy Treated HIV Infection
Article history: Received 9 May 2016 Accepted 9 May 2016 Available online 13 May 2016 (insulinemia N24.9 mIU/L, odds ratio [OR] 12.17%, p = 0.011), high tryglycerides (N2.85 mM, OR 4.18, p = 0.038) and lipodystorphy (OR 4.87, p= 0.015). Several studies have demonstrated that markers of inflammation, including levels of TNFR-I and II, are predictive ofmorbidity and mortality in persons infected ...
متن کاملHelicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.
BACKGROUND Helicobacter pylori coinfection in human immunodeficiency virus (HIV) patients has been associated with higher CD4+ cell counts and lower HIV-1 viral loads, with the underlying mechanisms being unknown. The objective of this study was to investigate the impact of H. pylori infection on markers of T-cell activation in HIV-positive and HIV-negative individuals. METHODS In a cross-sec...
متن کاملInflammation, immune activation, and CVD risk in individuals with HIV infection.
ANTIRETROVIRAL THERAPY (ART) PROLONGS LIFE, BUT individuals infected with human immunodeficiency virus (HIV) have a shorter life span than their uninfected counterparts and a greater than expected risk of cardiovascular disease (CVD). Part of the increased CVD risk associated with HIV infection can be attributed to an increased burden of traditional risk factors such as cigarette smoking, as we...
متن کاملImmune activation is associated with decreased thymic function in asymptomatic, untreated HIV-infected individuals
Background Reduced thymic function causes poor immunological reconstitution in human immunodeficiency virus (HIV)-positive patients on combined antiretroviral therapy (cART). The association between immune activation and thymic function in asymptomatic HIV-positive treatment-naive individuals has thus far not been investigated. Aims and objectives To optimise a five-colour flow cytometric ass...
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ژورنال
عنوان ژورنال: JAIDS Journal of Acquired Immune Deficiency Syndromes
سال: 2015
ISSN: 1525-4135
DOI: 10.1097/qai.0000000000000529